File:Thrombin generation curves with and without activated protein C and with various oral contraceptives with activated protein C.png

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Summary

Description
English: Thrombin generation curves without activated protein C (HPP -APC) and with activated protein C (HPP +APC) and with various oral contraceptives with activated protein C.

Original figure caption:

FIGURE 4 | Thrombin generation curves in absence (continuous line) and in presence of APC (dotted lines) of a healthy pooled plasma (blue) and women using combined oral contraceptives containing either ethinylestradiol (EE) with drospirenone (green), EE with desogestrel (yellow), EE with levonorgestrel (red), or estetrol with drospirenone (pink). The area under the curve represents the endogenous thrombin potential (ETP) parameter. In presence of APC, the ETP is higher with the use of combined oral contraceptives (e.g., drospirenone or desogestrel) compared to the healthy pooled plasma (composed of men and women not using hormonal contraception), leading to a resistance towards the APC. APC, activated protein C; DRSP, drospirenone; DSG, desogestrel; EE, ethinylestradiol; E4, estetrol; HPP, healthy pooled plasma; LNG, levonorgestrel.

Date
Source (2021). "Combined Oral Contraceptives and Venous Thromboembolism: Review and Perspective to Mitigate the Risk". Front Endocrinol (Lausanne) 12: 769187. DOI:10.3389/fendo.2021.769187. PMID 34956081. PMC: 8697849.
Author Morimont L, Haguet H, Dogné JM, Gaspard U, Douxfils J

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Public domain This chart is ineligible for copyright and therefore in the public domain, because it consists entirely of information that is common property and contains no original authorship. For more information, see Commons:Threshold of originality § Charts

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Date/TimeThumbnailDimensionsUserComment
current08:06, 22 February 2022Thumbnail for version as of 08:06, 22 February 20221,361 × 1,354 (501 KB)Vanished user 0x8cSXE0x6Uploaded a work by Morimont L, Haguet H, Dogné JM, Gaspard U, Douxfils J from {{cite journal | vauthors = Morimont L, Haguet H, Dogné JM, Gaspard U, Douxfils J | title = Combined Oral Contraceptives and Venous Thromboembolism: Review and Perspective to Mitigate the Risk | journal = Front Endocrinol (Lausanne) | volume = 12 | issue = | pages = 769187 | date = 2021 | pmid = 34956081 | pmc = 8697849 | doi = 10.3389/fendo.2021.769187 | url = }} with UploadWizard
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