HIST2H2BE

H2BC21
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4NFT
Identifiers
Aliases	H2BC21, GL105, H2B, H2B.1, H2BFQ, H2BGL105, H2BQ, histone cluster 2, H2be, histone cluster 2 H2B family member e, H2B clustered histone 21, HIST2H2BE, H2BE, H2B-GL105
External IDs	OMIM: 601831 HomoloGene: 128426 GeneCards: H2BC21
Gene location (Human)
Chr.	Chromosome 1 (human)
End	149,886,682 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; monocyte; ; left ventricle; ; right uterine tube; ; prostate; ; ganglionic eminence; ; gastrocnemius muscle; ; tibialis anterior muscle; ; olfactory bulb; ; skin of abdomen;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein heterodimerization activity; DNA binding;
Cellular component	chromosome; extracellular exosome; nucleoplasm; nucleosome; nucleus; extracellular space; cytosol;
Biological process	nucleosome assembly; innate immune response in mucosa; defense response to bacterium; antimicrobial humoral immune response mediated by antimicrobial peptide;
	Sources:Amigo / QuickGO
Orthologs
	8349
	n/a
	ENSG00000184678
	n/a
	Q16778
	n/a
	NM_003528
	n/a
	NP_003519
	n/a
	Wikidata
View/Edit Human

Histone H2B type 2-E is a protein that in humans is encoded by the HIST2H2BE gene.^[3]^[4]^[5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.^[5]

Cancer[edit]

HIST2H2BE gene has been detected progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.^[6] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184678 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Collart D, Romain PL, Huebner K, Pockwinse S, Pilapil S, Cannizzaro LA, Lian JB, Croce CM, Stein JL, Stein GS (Jan 1993). "A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing". J Cell Biochem. 50 (4): 374–85. doi:10.1002/jcb.240500406. PMID 1469070. S2CID 7732783.
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
^ ^a ^b "Entrez Gene: HIST2H2BE histone cluster 2, H2be".
^ ^a ^b Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.