(R)-p-Isothiocyanatobenzoylecgonine methyl ester

 (R)-p-Isothiocyanatobenzoylecgonine methyl ester  (p-ISOCOC) is a cocaine analogue and irreversible (covalent) binding inhibitor of the cocaine receptor, as well as irreversible blocker of dopamine uptake by DAT (the latter being unlike its C3 homologue m-Isococ). p-Isococ also blocks the high-affinity cocaine site in preference to the low-affinity site.