14-Cinnamoyloxycodeinone

14-Cinnamoyloxycodeinone is the most potent example in a series of opiate analgesic drugs discovered in the 1960s, with over 100 times the potency of morphine. It is a derivative of hydroxycodeinone, being the 14-cinnamate ester. In another paper, Buckett assigns the potency as 177 with a range (depending on animal and test) of 101–310×. It may be of interest to researchers that the allyl group in this compound and in allylprodine overlay very closely.