1916 Mississippi A&M Aggies football team

The 1916 Mississippi A&M Aggies football team represented The Agricultural and Mechanical College of the State of Mississippi (now known as Mississippi State University) as a member of the Southern Intercollegiate Athletic Association (SIAA) during the 1916 college football season. Led by third-year head coach Earl C. Hayes, the Aggies compiled an overall record of 4–4–1, with a mark of 3–4 in conference play. Mississippi A&M played home games at the New Athletic Field in Starkville, Mississippi.