1921 Giro di Lombardia

The 1921 Giro di Lombardia was the 17th edition of the Giro di Lombardia cycle race and was held on 10 November 1921, on a course of 261 km. The race started and finished in Milan. The race was won by the Italian Costante Girardengo, who reached the finish line at an average speed of 27.450 km/h, preceding his compatriots Gaetano Belloni and Federico Gay.

67 cyclists departed from Milan and 32 completed the race.