1921 Mississippi A&M Aggies football team

The 1921 Mississippi A&M Aggies football team was an American football team that represented the Agricultural and Mechanical College of the State of Mississippi (now known as Mississippi State University) as a member of the Southern Intercollegiate Athletic Association (SIAA) during the 1921 college football season. In their second season under head coach Ferdinand Holtkamp, Mississippi A&M compiled a 4–4–1 record.