1921 Sewanee Tigers football team

The 1921 Sewanee Tigers football team represented Sewanee: The University of the South during the 1921 college football season as a member of the Southern Intercollegiate Athletic Association (SIAA). The Tigers were led by head coach John Nicholson in his first season and finished with a record of six wins and two losses (6–2 overall, 4–2 in the SIAA).