1922 Washington University Pikers football team

The 1922 Washington University Pikers football team represented Washington University in St. Louis as a member of the Missouri Valley Conference (MVC) during the 1922 college football season. Led by George Rider in his third and final season as head coach, the Pikers compiled an overall record of 1–5–1 with a mark of 0–5–1 in conference play, placing last out of nine teams in the MVC. Washington University played home games at Francis Field in St. Louis.