1925 U.S. National Championships – Women's singles

First-seeded Helen Wills defeated Kathleen McKane Godfree 3–6, 6–0, 6–2 in the final to win the women's singles tennis title at the 1925 U.S. National Championships. The event was held at the West Side Tennis Club, Forest Hills, New York City. It was Wills's third consecutive U.S. National singles title.