1940 Mississippi Southern Southerners football team

The 1940 Mississippi Southern Southerners football team was an American football team that represented Mississippi Southern College (now known as the University of Southern Mississippi) as a member of the Southern Intercollegiate Athletic Association during the 1940 college football season. In their fourth year under head coach Reed Green, the team compiled a 7–4 record.

Mississippi Southern was ranked at No. 164 (out of 697 college football teams) in the final rankings under the Litkenhous Difference by Score system for 1940.