1941 Case Rough Riders football team

The 1941 Case Rough Riders football team represented the Case School of Applied Science in the American city of Cleveland, Ohio, now a part of Case Western Reserve University, during the 1941 college football season. The team was coached by Ray A. Ride, for whom the team mascot was named. The Case–Reserve rivalry game saw its 50th matchup, which began in 1891.

Case was ranked at No. 118 (out of 681 teams) in the final rankings under the Litkenhous Difference by Score System for 1941.