1941 East Texas State Lions football team

The 1941 East Texas State Lions football team represented the East Texas State Teachers College (later renamed the Texas A&M University–Commerce) as a member of the Lone Star Conference (LSC) during the 1941 college football season. In their seventh season under head coach Bob Berry, the Lions compiled a 6–2–1 record (2–2 against conference opponents) and finished third in the Lone Star Conference.

East Texas was ranked at No. 164 (out of 681 teams) in the final rankings under the Litkenhous Difference by Score System.

The team played its home games at East Texas Stadium in Commerce, Texas.