1941 USC Trojans football team

The 1941 USC Trojans football team was an American football team that represented the University of Southern California as a member of the Pacific Coast Conference during the 1941 college football season. The team was led by first-year head coach Sam Barry who took over after Howard Jones died during the previous off-season. Barry also coached USC's basketball and baseball teams. The Trojans compiled a 2–6–1 record (2–4–1 against PCC opponents) and finished eighth out of ten in the conference.

USC was ranked at No. 64 (out of 681 teams) in the final rankings under the Litkenhous Difference by Score System for 1941.