1942–43 Segunda División

Overview before the season
24 teams joined the league, including two relegated from the 1941–42 La Liga and 3 promoted from Divisiones Regionales.


 * Relegated from La Liga:
 * Hércules
 * Real Sociedad


 * Promoted from Divisiones Regionales:
 * Cultural Leonesa
 * Tarrasa
 * Alcoyano