1942 Iowa State Teachers Panthers football team

The 1942 Iowa State Teachers Panthers football team represented Iowa State Teachers College in the North Central Conference during the 1942 college football season. In its fifth season under head coach Clyde Starbeck, the team compiled a 6–1 record (5–0 against NCC opponents) and won the conference championship.

Iowa State Teachers was ranked at No. 108 (out of 590 college and military teams) in the final rankings under the Litkenhous Difference by Score System for 1942.

The team played its home games at O. R. Latham Stadium in Cedar Falls, Iowa.