1942 Lafayette Leopards football team

The 1942 Lafayette Leopards football team was an American football team that represented Lafayette College in the Middle Three Conference during the 1942 college football season. In its sixth season under head coach Edward Mylin, the team compiled a 3–5–1 record. Charles Nagle was the team captain.

Lafayette was ranked at No. 139 (out of 590 college and military teams) in the final rankings under the Litkenhous Difference by Score System for 1942.

The team played its home games at Fisher Field in Easton, Pennsylvania.