1942 San Francisco Dons football team

The 1942 San Francisco Dons football team was an American football team that represented the University of San Francisco as an independent during the 1942 college football season. In their first season under head coach Al Tassi, the Dons compiled a 6–4 record and outscored their opponents by a combined total of 221 to 106.

San Francisco was ranked at No. 66 (out of 590 college and military teams) in the final rankings under the Litkenhous Difference by Score System for 1942.