1942 Southern Illinois Maroons football team

The 1942 Southern Illinois Maroons football team was an American football team that represented Southern Illinois Normal University (now known as Southern Illinois University Carbondale) in the Illinois Intercollegiate Athletic Conference (IIAC) during the 1942 college football season. Under fourth-year head coach Glenn Martin, the team compiled a 2–4 record.

Southern Illinois was ranked at No. 505 (out of 590 college and military teams) in the final rankings under the Litkenhous Difference by Score System for 1942.

The team played its home games at McAndrew Stadium in Carbondale, Illinois.