1943 Charleston Coast Guard Sailors football team

The 1943 Charleston Coast Guard Sailors football team represented the United States Coast Guard in Charleston, South Carolina, during the 1943 college football season. Led by head coach Mark Brashares, the Sailors compiled a record of 5–4.

In the final Litkenhous Ratings, Charleston Coast Guard ranked 106th among the nation's college and service teams with a rating of 64.4.