1943 Holy Cross Crusaders football team

The 1943 Holy Cross Crusaders football team was an American football team that represented the College of the Holy Cross as an independent during the 1943 college football season. In its second year under head coach Ank Scanlan, the team compiled a 6–2 record. The team played its home games at Fitton Field in Worcester, Massachusetts.

In the final Litkenhous Ratings, Holy Cross ranked 43rd among the nation's college and service teams with a rating of 85.1.