1943 Oklahoma Sooners football team

The 1943 Oklahoma Sooners football team represented the University of Oklahoma in the 1943 college football season. In their third year under head coach Dewey Luster, the Sooners compiled a 7–2 record (5–0 against conference opponents), won the Big Six Conference championship, and outscored their opponents by a combined total of 187 to 92.

No Sooners received All-America honors in 1943, but six Sooners received all-conference honors: Bob Brumley (back), Gale Fulgham (guard), Lee Kennon (tackle), W.G. Lamb (end), Derald Lebow (back), and Bob Mayfield (center).

In the final Litkenhous Ratings, Oklahoma ranked 41st among the nation's college and service teams with a rating of 85.7.

NFL draft
The following players were drafted into the National Football League following the season.