1943 Xavier Musketeers football team

The 1943 Xavier Musketeers football team was an American football team that represented Xavier University as an independent during the 1943 college football season. In their ninth year under head coach Clem Crowe, the Musketeers compiled a 1–6 record.

In the final Litkenhous Ratings, Xavier ranked 215th among the nation's college and service teams with a rating of 30.7.