1945 Eastern Illinois Panthers football team

The 1945 Eastern Illinois Panthers football team represented Eastern Illinois University as a member of the Illinois Intercollegiate Athletic Conference (IIAC) during the 1945 college football season. The team was led by first-year head coach James Goff and played their home games at Schahrer Field in Charleston, Illinois. The Panthers finished the season with a 2–3–2 record overall and a 1–1–2 record in conference play.