1945 U.S. National Championships – Men's singles

Frank Parker defeated Bill Talbert 14–12, 6–1, 6–2 in the final to win the men's singles tennis title at the 1945 U.S. National Championships.

Seeds
The seeded players are listed below. Frank Parker is the champion; others show the round in which they were eliminated.


 * 1) 🇺🇸 Frank Parker (champion)
 * 2)  Andrés Hammersley (second round)
 * 3) 🇺🇸 Bill Talbert (finalist)
 * 4) 🇦🇷 Heraldo Weiss (first round)
 * 5) 🇪🇨 Pancho Segura (semifinals)
 * 6) 🇦🇷 Alejo Russell (quarterfinals)
 * 7) 🇺🇸 Gardnar Mulloy (second round)
 * 8)  Ladislav Hecht (second round)
 * 9) 🇺🇸 Frank Shields (third round)
 * 10) 🇲🇽 Francisco Guerrero-Arcocha (second round)
 * 11) 🇺🇸 Elwood Cooke (semifinals)
 * 12) 🇨🇦 Henri Rochon (first round)
 * 13) 🇺🇸 Seymour Greenberg (quarterfinals)
 * 14) 🇨🇦 Brendan Macken (second round)
 * 15) 🇺🇸 Robert Falkenburg (quarterfinals)

Key

 * Q = Qualifier
 * WC = Wild card
 * LL = Lucky loser
 * r = Retired