1946 Holy Cross Crusaders football team

The 1946 Holy Cross Crusaders football team was an American football team that represented the College of the Holy Cross as an independent during the 1946 college football season. In its second year under head coach Ox DaGrosa, the team compiled a 5–4 record.

The Crusaders led the nation in passing defense, giving up only 53.7 passing yards per game. They also ranked thirteenth in total defense, allowing 178.8 yards per game.

Holy Cross was ranked at No. 55 in the final Litkenhous Difference by Score System rankings for 1946.

The team played its home games at Fitton Field in Worcester, Massachusetts.

After the season
The 1947 NFL Draft was held on December 16, 1946. The following Crusaders were selected.