1946 Mississippi Southern Southerners football team

The 1946 Mississippi Southern Southerners football team represented Mississippi Southern College (now known as the University of Southern Mississippi) in the 1946 college football season. The team played in the Bacardi Bowl against the University of Havana.

Mississippi Southern was ranked at No. 64 in the final Litkenhous Difference by Score System rankings for 1946.

After the season
The 1947 NFL Draft was held on December 16, 1946. The following Southerner was selected.