1946 Southwest Texas State Bobcats football team

The 1946 Southwest Texas State Bobcats football team was an American football team that represented Southwest Texas State Teachers College (now known as Texas State University) during the 1946 college football season as a member of the Lone Star Conference (LSC). In their first year under head coach George Vest, the team compiled an overall record of 6–2–2 with a mark of 3–2 in conference play.

Southwest Texas was ranked at No. 100 in the final Litkenhous Difference by Score System rankings for 1946.