1948 Eastern Illinois Panthers football team

The 1948 Eastern Illinois Panthers football team represented Eastern Illinois State College—now known as Eastern Illinois University—as a member of the Illinois Intercollegiate Athletic Conference (IIAC) during the 1948 college football season. Led by third-year head coach Maynard O'Brien, the Panthers finished the season with a 7–3 record overall and a 4–0 mark in conference play, winning the IIAC. They were invited to the postseason Corn Bowl, where they lost to, 6–0.

Eastern Illinois was ranked at No. 187 in the final Litkenhous Difference by Score System ratings for 1948.