1948 Mississippi Southern Southerners football team

The 1948 Mississippi Southern Southerners football team was an American football team that represented Mississippi Southern College (now known as the University of Southern Mississippi) as a member of the Gulf States Conference during the 1948 college football season. In their ninth year under head coach Reed Green, the team compiled a 7–3 record.

Mississippi Southern was ranked at No. 108 in the final Litkenhous Difference by Score System ratings for 1948.