1950 Holy Cross Crusaders football team

The 1950 Holy Cross Crusaders football team was an American football team that represented the College of the Holy Cross as an independent during the 1950 college football season. In its seventh, non-consecutive year under head coach Eddie Anderson, the team compiled a 4–5–1 record.

Johnny Turco ranked fifth in major college football in 1950 with 102 points scored on 16 touchdowns. Chuck Maloy ranked ninth nationally with 104 pass completions (good for 1,572 yards), but his completion percentage was 43.0% and he threw 19 interceptions.

The team played its home games at Fitton Field in Worcester, Massachusetts.