1961 Wyoming Cowboys football team

The 1961 Wyoming Cowboys football team was an American football team that represented the University of Wyoming in the Skyline Conference during the 1961 college football season. In their fifth and final season under head coach Bob Devaney, the Cowboys played their home games on campus at War Memorial Stadium in Laramie, Wyoming. They compiled a 6–1–2 record (5–0–1 in Skyline, first), tied for the conference championship, and outscored their opponents 171 to 74.

The team's statistical leaders included Andy Melosky with 464 passing yards, Chuck Lamson with 451 rushing yards, and Mike Walker with 468 receiving yards and 30 points scored.

After the season in February, Devaney departed for the University of Nebraska in Lincoln, and defensive line coach Lloyd Eaton was promoted.