1965 U.S. National Championships – Men's singles

Manuel Santana defeated Cliff Drysdale 6–2, 7–9, 7–5, 6–1 in the final to win the men's singles tennis title at the 1965 U.S. National Championships.

Seeds
The seeded players are listed below. Manuel Santana is the champion; others show the round in which they were eliminated.


 * 1) 🇦🇺 Roy Emerson (quarterfinals)
 * 2) 🇦🇺 Fred Stolle (second round)
 * 3) 🇺🇸 Dennis Ralston (quarterfinals)
 * 4) 🇪🇸 Manuel Santana (champion)
 * 5) 🇺🇸 Arthur Ashe (semifinals)
 * 6) 🇲🇽 Rafael Osuna (semifinals)
 * 7) 🇺🇸 Chuck McKinley (fourth round)
 * 8) Cliff Drysdale (finalist)

Key

 * Q = Qualifier
 * WC = Wild card
 * LL = Lucky loser
 * r = Retired