1966 Prairie View A&M Panthers football team

The 1966 Prairie View A&M Panthers football team represented Prairie View A&M College of Texas (now known as Prairie View A&M University) as a member of the Southwestern Athletic Conference (SWAC) during the 1966 NCAA College Division football season. Led by first-year head coach Hoover J. Wright, the Panthers compiled an overall record of 5–3–1, with a conference record of 3–3–1, and finished tied for fourth in the SWAC.