1969 Prairie View A&M Panthers football team

The 1969 Prairie View A&M Panthers football team represented Prairie View A&M College of Texas (now known as Prairie View A&M University) as a member of the Southwestern Athletic Conference (SWAC) during the 1969 NCAA College Division football season. Led by first-year head coach Alexander Durley, the Panthers compiled an overall record of 4–5, with a conference record of 3–4, and finished fifth in the SWAC.