1972 Mississippi Valley State Delta Devils football team

The 1972 Mississippi Valley State Delta Devils football team represented Mississippi Valley State College (now known as Mississippi Valley State University) as a member of the Southwestern Athletic Conference (SWAC) during the 1972 NCAA College Division football season. Led by third-year head coach Davis Weathersby, the Delta Devils compiled an overall record of 5–5, with a conference record of 1–5, and finished tied for fifth in the SWAC.