1977–78 La Salle Explorers men's basketball team

The 1977–78 La Salle Explorers men's basketball team represented La Salle University as a member of the East Coast Conference during the 1977–78 NCAA Division I men's basketball season. The team was led by head coach Paul Westhead and played their home games at The Palestra in Philadelphia, Pennsylvania. After finishing atop the ECC East division standings, the Explorers won the ECC tournament to receive a bid to the NCAA tournament. As the No. 4 at-large seed in the East region, La Salle lost to the No. 2 qualifying seed Villanova in the opening round. The team finished with a record of 18–12 (7–0 ECC).

Schedule and results
!colspan=9 style=| Regular season

!colspan=9 style=| ECC Tournament

!colspan=9 style=| NCAA Tournament