1978 Cal Poly Mustangs football team

The 1978 Cal Poly Mustangs football team represented California Polytechnic State University, San Luis Obispo as a member of the California Collegiate Athletic Association (CCAA) during the 1978 NCAA Division II football season. Led by 11th-year head coach Joe Harper, Cal Poly compiled an overall record of 7–3 with a mark of 2–0 in conference play, winning the CCAA title for the third consecutive season. The Mustangs advanced to the NCAA Division II Football Championship playoffs for the first time, where they lost to in the quarterfinals. Cal Poly played home games at Mustang Stadium in San Luis Obispo, California.