1978 Colorado Buffaloes football team

The 1978 Colorado Buffaloes football team represented the University of Colorado in the Big Eight Conference during the 1978 NCAA Division I-A football season. Led by fifth-year head coach Bill Mallory, the Buffaloes compiled an overall record of 6–5 with a mark of 2–5 in conference play, placing seventh in the Big 8. Colorado played home games on campus at Folsom Field in Boulder, Colorado.

Colorado again won its first five games, all at home, but then lost five of six and Mallory was fired on November 21 by athletic director Eddie Crowder, the previous head coach. Mallory was succeeded by Chuck Fairbanks, the head coach of the New England Patriots in the National Football League (NFL) for six years and formerly at conference foe Oklahoma (1967–72).

The next winning season for Colorado was seven years later, in 1985.