1978 Holy Cross Crusaders football team

The 1978 Holy Cross Crusaders football team was an American football team that represented the College of the Holy Cross as an independent during the 1978 NCAA Division I-A football season. Neil Wheelwright returned for his third year as head coach. The team compiled a record of 7–4.

All home games were played at Fitton Field on the Holy Cross campus in Worcester, Massachusetts.

Statistical leaders
Statistical leaders for the 1978 Crusaders included:
 * Rushing: Crocky Nangle, 394 yards and 3 touchdowns on 89 attempts
 * Passing: Peter Colombo, 1,432 yards, 103 completions and 7 touchdowns on 212 attempts
 * Receiving: Chuck Mullen, 587 yards and 6 touchdowns on 40 receptions
 * Scoring: Brian Doherty, 42 points from 7 touchdowns
 * Total offense: Peter Colombo, 1,517 yards (1,432 passing, 85 rushing)
 * All-purpose yards: Larry Ewald, 684 yards (392 rushing, 156 returning, 136 receiving)
 * Interceptions: Glenn Verrette, 7 interceptions for 164 yards