1978 NCAA Division II baseball tournament

The 1978 NCAA Division II baseball tournament was the postseason tournament hosted by the NCAA to determine the national champion of baseball among its Division II colleges and universities at the end of the 1978 NCAA Division II baseball season.

Florida Southern defeated Delta State in the championship game of the double-elimination tournament, 7–2, winning the Moccasins' fourth national title. Florida Southern were coached by Joe Arnold.

Regionals
The regionals consisted 32 teams in eight groupings. Each regional consisted of a 4-team bracket. All brackets were double elimination format. The top team in each bracket advanced to the 1978 Division II College World Series.

New England Regional
(3–0) (2–2)  (1–2)  (0–2)

New Haven won regional

Middle Atlantic Regional
(3–1) (3–2)  (1–2)  (0–2)

Le Moyne won regional

South Atlantic Regional
(3–0) (2–2)  (1–2)  (0–2)

Valdosta State won regional

South Regional
(3–0) (2–2)  (1–2)  (0–2)

Florida Southern won regional

Great Lakes Regional
(4–1) (2–2)  (1–2)  (0–2)

Eastern Illinois won regional

North Central Regional
(3–0) (2–2)  (1–2)  (0–2)

Southwest Missouri State won regional

South Central Regional
(3–1) (3–2)  (1–2)  (0–2)

Delta State won regional

West Regional
(4–1) {{CBSB link|year=1978|team=Chapman Panthers (2–2) {{CBSB link|year=1978|team=UC Davis Aggies|title=UC Davis}} (1–2) {{CBSB link|year=1978|team=Chico State Wildcats|title=Chico State (0–2)

San Diego won regional