1978 Prairie View A&M Panthers football team

The 1978 Prairie View A&M Panthers football team represented Prairie View A&M University as a member of the Southwestern Athletic Conference (SWAC) during the 1978 NCAA Division I-AA football season. Led by ninth-year head coach Hoover J. Wright, the Panthers compiled an overall record of 3–7, with a conference record of 1–5, and finished seventh in the SWAC.