1978 Queen's Club Championships – Singles

Raúl Ramírez was the defending champion but lost in the first round to Victor Amaya.

Tony Roche won the singles title at the 1978 Queen's Club Championships tennis tournament defeating John McEnroe in the final 8–6, 9–7.

Seeds

 * 1) 🇲🇽 Raúl Ramírez (first round)
 * 2) 🇺🇸 Sandy Mayer (semifinals)
 * 3)  Ilie Năstase (first round)
 * 4) 🇺🇸 John McEnroe (final)
 * 5) 🇺🇸 Tim Gullikson (first round)
 * 6) 🇦🇺 John Alexander (quarterfinals)
 * 7) 🇦🇺 John Newcombe (third round)
 * 8) 🇮🇹 Adriano Panatta (first round)
 * 9)  Jaime Fillol (third round)
 * 10) 🇦🇺 Phil Dent (second round)
 * 11) 🇬🇧 John Lloyd (quarterfinals)
 * 12) n/a
 * 13) 🇺🇸 Hank Pfister (second round)
 * 14) 🇬🇧 Mark Cox (first round)
 * 15) 🇺🇸 Tom Leonard (first round)
 * 16) 🇺🇸 Jeff Borowiak (first round)