1979–80 Penn Quakers men's basketball team

The 1979–80 Penn Quakers men's basketball team represented the University of Pennsylvania as a member of the Ivy League during the 1979–80 NCAA Division I men's basketball season. Led by head coach Bob Weinhauer, the Quakers played their home games at The Palestra in Philadelphia. A year after reaching the Final Four, Penn again finished as Ivy League champions by defeating co-champion Princeton in a play-in game to receive an automatic bid to the NCAA tournament. Playing as the No. 12 seed in the Mideast region, the Quakers defeated No. 5 seed Washington State in the opening round, before losing to No. 4 seed Duke in the second round.