1980–81 Club Universidad Nacional season

The 1980–81 season was the 20th season of Club Universidad Nacional, commonly referred to as UNAM, in the top flight of Mexican football. In addition to the domestic league, UNAM participated in this season's editions of the CONCACAF Champions' Cup, and the Copa Interamericana.

CONCACAF Champions' Cup
UNAM entered the tournament in the third round, after their opponent withdrew from the competition in the first round.