1980–81 DePaul Blue Demons men's basketball team

The 1980–81 DePaul Blue Demons men's basketball team represented DePaul University during the 1980–81 NCAA Division I men's basketball season. They were led by head coach Ray Meyer, in his 39th season, and played their home games at the brand new Rosemont Horizon in Rosemont.

Schedule and results
!colspan=12 style=| Regular season

!colspan=12 style=| NCAA Tournament

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