1980–81 Houston Cougars men's basketball team

The 1980–81 Houston Cougars men's basketball team represented the University of Houston in NCAA Division I competition in the 1980–81 season.

Houston, coached by Guy Lewis, played its home games in the Hofheinz Pavilion in Houston, Texas, and was then a member of the Southwest Conference.

Schedule and results
!colspan=9 style=| Regular season

!colspan=9 style=| SWC Tournament

!colspan=9 style=| NCAA Tournament