1980–81 Mexican Primera División season

Statistics of Primera División de México for the 1980–81 season.

Overview
It was contested by 20 teams, and UNAM won the championship.

Atletas Campesinos was promoted from Segunda División.

Unión de Curtidores was relegated to Segunda División.

Relegation play-offs
''Atlas won 2-3 on aggregate. Unión de Curtidores was relegated to Segunda División.''

Final
UNAM won 4-2 on aggregate.