1980–81 Midland Football Combination

The 1980–81 Midland Football Combination season was the 44th in the history of Midland Football Combination, a football competition in England.

Division One
Division One featured 18 clubs which competed in the division last season along with two new clubs, promoted from Division Two:
 * Hurley Daw Mill Miners Welfare
 * Smethwick Highfield