1980–81 Purdue Boilermakers men's basketball team

The 1980–81 Purdue Boilermakers men's basketball team represented Purdue University during the 1980–81 college basketball season. The Boilermakers were led by first-year head coach Gene Keady and finished with an overall record of 21–11 (10–8 Big Ten).

Schedule and results
!colspan=9 style=|Non-Conference Regular Season

!colspan=9 style=|Big Ten Regular Season

!colspan=9 style=|National Invitation Tournament